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Continuation pago A

APPLICATION FOR RESEARCH GRANT

SECTION I

1. ABBREVIATED TITLE OF RESEARCH PROPOSAL (Do not exceed 33 17pewriter spaces)

The Effects of Childhood Plumbism on CNS Integrity

2 TYPE OF APPLICATION (Check one) NEW PROACT

RENEWAL OF PMS GRANT NO

ISTRUOTIONS: This Continuation pago is provided for cohon die or nero Apptionate join in the submission of an APPLICATION EVA FECRARCH GRANT, 2010-523,

to accommodate the documentation of nanos of all cuch applicant organizations and the roquired signaturos of tho officials authoricod to sign and obligato locally coch Applicant's funds to be used for the purpoco of tháo cxplication.

thon used, this page 1A ohould be prepared in five copics for Amcorperatdem
application following pago 1.
On maso
4tcolf, in the opacco mmbored 20,
and 178, insort (typo or print) on oll cepion Shoco Merdas

NAME AND ADDRESS OF APPLICANT ORGANIZATION

State University of New York Downstate Medical Center

450 Clarkson Avenue, Brooklyn, New York 11203

NAME, SOCIAL SECURITY NUMBER, OFFICIAL TITLE, AND DEPARTMENT OF ALL PROFESSIONAL PERSONNEL ENGAGED ON
PROJECT, BEGINNING WITH PRINCIPAL INVESTIGATOR

Allen, John E., 283-16-9469

Winsberg, Bertrand G., 318-30-1210

Professor of Pediatrics - Dept. of Pediatrics
State University of New York Downstate Medical ar.

Director, Child Psychiatric Evaluation Unit,
N. Y. S. Dept. of Mental Hygiene,

Dept. Child Psychiatry-Downstate Medical Center

TITLE OF PROJECT

The Effects of Childhood Plumbism on CNS Integrity

USE THIS SPACE TO ABSTRACT YOUR PROPOSED RESEARCH. OUTLINE OBJECTIVES AND METHODS. UNDERSCORE THE KEY WORDS (NOT TO EXCEED 10) IN YOUR ABSTRACT.

Two prospective cohort studies, with 100 subjects in each, are proposed in order
to investigate two questions: (1) the effect of childhood plumbism without mental
deficiency on behavior, achievement and other indices of CNS integrity and (2)
the effect of chelation treatment for plumbism on CNS integrity.

In order to investigate the first question, it is proposed that two groups of children, who are found to be developmentally and neurologically normal by the Gesell Developmental Inventory, be followed and evaluated at periodic intervals with a number of neuropsychiatric exams for a seven year period of time. The two groups will differ in respect to blood-lead levels. The Experimental group will have a blood-lead level 80 micrograms percent or higher while the Control group will have a blood-lead level 30 micrograms percent or lower. It is hypothesized that the Experimental group will not perform as well as the Control group on tests of CNS integrity.

In order to investigate the second question, the effect of chelation therapy on CNS integrity, it is proposed that two groups of asymptomatic lead-burdened children (defined as blood-lead level between 60 micrograms percent and 80 micrograms percent) be followed. One group will be treated with chelating drugs, as is done in numerous lead-control programs throughout the country, while the other cohort will not be treated with chelating agents as is the current policy at KCH with asymptomatic lead-burdened children. The two groups will be followed over a period of time and signs of developmental or neurological aberrations will be noted.

CONSULTANT COSTS_System Analyists/Computer Programmer P.T. @ $15/hr.

9,890

OTHER EXPENSES (Itemize) Car Rental @ $200.00 per mo.

Psychological testing material
Computer time 61 hrs. $60.00 per hr.
Keypunch service

TOTAL DIRECT COST (Enter on Page 1, Item 5)

INDIRECT
COST

2,400

500

420

$116,267

(See Instructions)

PHS 398

*IF THIS IS A SPECIAL RATE (eg, off-site), SO INDICATE.

Pace ?

JUDGET ESTIMATES POK ALL YEARS OF SUPPORT REQUESTED FROM PUBLIC HEALTH SERVICE

REMARKS: Justify all costs for the first year for which the need may not be obvious. For future years, justify equipment costs, as well as any significant increases in any other category. If a recurring annual increase in personnel costs is requested, give percentage. (Use continuation page if needed.)