Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We UseOxford University Press, 7 сент. 2006 г. - Всего страниц: 336 The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. |
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Стр. 25
... (EGFR). In a Science paper,23 Levitzki and colleagues revealed that a series of simple dicyanobenzylidenes and carboxybenzylidenes could block EGF-dependent cell proliferation. They were among the first selective small-molecule EGFR ...
... (EGFR). In a Science paper,23 Levitzki and colleagues revealed that a series of simple dicyanobenzylidenes and carboxybenzylidenes could block EGF-dependent cell proliferation. They were among the first selective small-molecule EGFR ...
Стр. 30
... EGFR, a sibling of HER-2/neu, because EGF had been implicated in one-third of all cancers by then. The Sato and Mendelsohn groups toiled in their laboratories for 2 years trying to clone a monoclonal antibody that would block EGFR. Even ...
... EGFR, a sibling of HER-2/neu, because EGF had been implicated in one-third of all cancers by then. The Sato and Mendelsohn groups toiled in their laboratories for 2 years trying to clone a monoclonal antibody that would block EGFR. Even ...
Стр. 31
... EGFR was partially responsible for the success of several targeted cancer drugs delineated here. Sato, having been born on a farm, is very much concerned with solving world hunger. He quit his lucrative teaching position and went to ...
... EGFR was partially responsible for the success of several targeted cancer drugs delineated here. Sato, having been born on a farm, is very much concerned with solving world hunger. He quit his lucrative teaching position and went to ...
Стр. 34
... EGFR inhibitor at the intracellular domain level. Unlike Herceptin, which has to be administered by infusion, Iressa is an oral small-molecule EGFR tyrosine kinase inhibitor (TKI). On the cellular level, antibodies such as Herceptin ...
... EGFR inhibitor at the intracellular domain level. Unlike Herceptin, which has to be administered by infusion, Iressa is an oral small-molecule EGFR tyrosine kinase inhibitor (TKI). On the cellular level, antibodies such as Herceptin ...
Стр. 35
... EGFR inhibitor, was approved in 2004 for the treatment of non-small-cell lung cancer. Its mechanism of action is the same as that of Iressa. It blocks the tumor cell growth by inhibiting the tyrosine kinase activity of the EGFR, thereby ...
... EGFR inhibitor, was approved in 2004 for the treatment of non-small-cell lung cancer. Its mechanism of action is the same as that of Iressa. It blocks the tumor cell growth by inhibiting the tyrosine kinase activity of the EGFR, thereby ...
Содержание
3 | |
2 Drugs to Kill Germs | 43 |
From Nitroglycerin to Lipitor | 75 |
4 Sex and Drugs | 103 |
5 Drugs of the Mind | 129 |
6 Diabetes Drugs | 165 |
7 Anesthetics | 187 |
8 AntiInflammatory Drugs | 213 |
9 Reflections | 241 |
Chemical Structures | 245 |
Trademarks of the Drugs | 277 |
Bibliography | 281 |
Index | 295 |
Другие издания - Просмотреть все
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Часто встречающиеся слова и выражения
ACE inhibitors acid active agents alcohol anesthesia anesthetic antibacterial antibiotics antidepressants aphrodisiac approved aspirin Avastin Banting barbiturates became beta-blockers biological blood breast cancer Bristol-Myers Squibb calcium cancer drugs cause cells Chain chemical chemist chemistry chemotherapy chloroform chlorpromazine cholesterol clinical trials cocaine compounds cortisone depression developed diabetes discovered disease doses drug discovery EGFR enzyme estrogen ether extract Florey Gleevec guinea pigs haloperidol heart hormone human inhibit inhibitors initially injection insulin Iressa isolated kinase laboratory later leukemia leukotriene Lilly Lipitor lithium liver Macleod Marsilid medicine Merck metabolism mevastatin million molecule Morton nitroglycerin nitrous oxide Nobel Prize Novartis oral pancreas Parke-Davis patients penicillin Pfizer pharmaceutical Physiology production Prontosil prostaglandin protease protein Prozac receptor rheumatoid arthritis Roche scientists serotonin side effects Squibb statins streptomycin sulfanilamide Syntex synthesis tamoxifen Taxol tested therapy tion toxic trade name treating treatment tuberculosis tumors University Viagra virus Waksman