Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We UseOxford University Press, 7 сент. 2006 г. - Всего страниц: 336 The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. |
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Стр. 14
... Taxol Paclitaxel, with the trade name Taxol, has had considerable success in treating ovarian and breast cancer since 1992. It was initially isolated from the Pacific yew tree as part of the National Cancer Institute-United States ...
... Taxol Paclitaxel, with the trade name Taxol, has had considerable success in treating ovarian and breast cancer since 1992. It was initially isolated from the Pacific yew tree as part of the National Cancer Institute-United States ...
Стр. 15
... Taxol's structure was a long and frustrating endeavor. Wani described Wall as “a go-getter” and “a very dedicated scientist,” whose “persistence was his greatest virtue, but patience was not.”16 Therefore, Wall directed Wani to work on ...
... Taxol's structure was a long and frustrating endeavor. Wani described Wall as “a go-getter” and “a very dedicated scientist,” whose “persistence was his greatest virtue, but patience was not.”16 Therefore, Wall directed Wani to work on ...
Стр. 16
... Taxol, with tax signifying the origin of the molecule from Taxus brevifolia and ol indicating that the molecule contained one or more alcohol functionalities. In 1971, Wall and coworkers published the structure of Taxol, which contained ...
... Taxol, with tax signifying the origin of the molecule from Taxus brevifolia and ol indicating that the molecule contained one or more alcohol functionalities. In 1971, Wall and coworkers published the structure of Taxol, which contained ...
Стр. 17
... Taxol from the beginning, more than 20 years previously. However, the NCI was not set up to take on the expensive and long Phase III trials that involved numerous ... Taxol is about 400 kilograms per year. Currently, Taxol cancer drugs 17.
... Taxol from the beginning, more than 20 years previously. However, the NCI was not set up to take on the expensive and long Phase III trials that involved numerous ... Taxol is about 400 kilograms per year. Currently, Taxol cancer drugs 17.
Стр. 18
... Taxol is produced in large fermentation tanks using plant cells. Taxol is one of the best weapons in an oncologist's arsenal, and many even refer to times prior to 1994 as the “pre-Taxol” era. Interestingly, a major new use of Taxol is ...
... Taxol is produced in large fermentation tanks using plant cells. Taxol is one of the best weapons in an oncologist's arsenal, and many even refer to times prior to 1994 as the “pre-Taxol” era. Interestingly, a major new use of Taxol is ...
Содержание
3 | |
2 Drugs to Kill Germs | 43 |
From Nitroglycerin to Lipitor | 75 |
4 Sex and Drugs | 103 |
5 Drugs of the Mind | 129 |
6 Diabetes Drugs | 165 |
7 Anesthetics | 187 |
8 AntiInflammatory Drugs | 213 |
9 Reflections | 241 |
Chemical Structures | 245 |
Trademarks of the Drugs | 277 |
Bibliography | 281 |
Index | 295 |
Другие издания - Просмотреть все
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Часто встречающиеся слова и выражения
ACE inhibitors acid active agents alcohol anesthesia anesthetic antibacterial antibiotics antidepressants aphrodisiac approved aspirin Avastin Banting barbiturates became beta-blockers biological blood breast cancer Bristol-Myers Squibb calcium cancer drugs cause cells Chain chemical chemist chemistry chemotherapy chloroform chlorpromazine cholesterol clinical trials cocaine compounds cortisone depression developed diabetes discovered disease doses drug discovery EGFR enzyme estrogen ether extract Florey Gleevec guinea pigs haloperidol heart hormone human inhibit inhibitors initially injection insulin Iressa isolated kinase laboratory later leukemia leukotriene Lilly Lipitor lithium liver Macleod Marsilid medicine Merck metabolism mevastatin million molecule Morton nitroglycerin nitrous oxide Nobel Prize Novartis oral pancreas Parke-Davis patients penicillin Pfizer pharmaceutical Physiology production Prontosil prostaglandin protease protein Prozac receptor rheumatoid arthritis Roche scientists serotonin side effects Squibb statins streptomycin sulfanilamide Syntex synthesis tamoxifen Taxol tested therapy tion toxic trade name treating treatment tuberculosis tumors University Viagra virus Waksman