Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We UseOxford University Press, 7 сент. 2006 г. - Всего страниц: 336 The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. |
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Стр. ix
... agent. Most people who have engaged in this effort for a lifetime have not been so fortunate. It is not easy to select a research objective that will turn out to be a winner. The enormous complexity of the human body (especially in ...
... agent. Most people who have engaged in this effort for a lifetime have not been so fortunate. It is not easy to select a research objective that will turn out to be a winner. The enormous complexity of the human body (especially in ...
Стр. xiii
... of HIV protease inhibitors and reverse transcriptase inhibitors as antiviral agents have transformed AIDS from a death sentence to a disease that can be controlled. In preparing this manuscript, I have had the great fortune.
... of HIV protease inhibitors and reverse transcriptase inhibitors as antiviral agents have transformed AIDS from a death sentence to a disease that can be controlled. In preparing this manuscript, I have had the great fortune.
Стр. 4
... agents such as chemicals, X-ray, and ultraviolet light) were to blame, whereas the other thought that viruses were the culprits. The carcinogen theory took root first. As early as 1775, British doctor Percival Pott made the astute ...
... agents such as chemicals, X-ray, and ultraviolet light) were to blame, whereas the other thought that viruses were the culprits. The carcinogen theory took root first. As early as 1775, British doctor Percival Pott made the astute ...
Стр. 7
... agent, a carcinogen. However, oncogenes are normally kept inactive by tumor-suppressing genes. In some cases those controlling genes may be mutated or removed, allowing oncogenes to run rampant. For a tumor to develop, one has to lose ...
... agent, a carcinogen. However, oncogenes are normally kept inactive by tumor-suppressing genes. In some cases those controlling genes may be mutated or removed, allowing oncogenes to run rampant. For a tumor to develop, one has to lose ...
Стр. 9
... agents. His experience proved invaluable in solving the Bari mystery, and he quickly determined that mustard was indeed the culprit in the catastrophe. Subsequent autopsies of 617 victims revealed that mustard gas destroyed most of ...
... agents. His experience proved invaluable in solving the Bari mystery, and he quickly determined that mustard was indeed the culprit in the catastrophe. Subsequent autopsies of 617 victims revealed that mustard gas destroyed most of ...
Содержание
3 | |
2 Drugs to Kill Germs | 43 |
From Nitroglycerin to Lipitor | 75 |
4 Sex and Drugs | 103 |
5 Drugs of the Mind | 129 |
6 Diabetes Drugs | 165 |
7 Anesthetics | 187 |
8 AntiInflammatory Drugs | 213 |
9 Reflections | 241 |
Chemical Structures | 245 |
Trademarks of the Drugs | 277 |
Bibliography | 281 |
Index | 295 |
Другие издания - Просмотреть все
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Часто встречающиеся слова и выражения
ACE inhibitors acid active agents alcohol anesthesia anesthetic antibacterial antibiotics antidepressants aphrodisiac approved aspirin Avastin Banting barbiturates became beta-blockers biological blood breast cancer Bristol-Myers Squibb calcium cancer drugs cause cells Chain chemical chemist chemistry chemotherapy chloroform chlorpromazine cholesterol clinical trials cocaine compounds cortisone depression developed diabetes discovered disease doses drug discovery EGFR enzyme estrogen ether extract Florey Gleevec guinea pigs haloperidol heart hormone human inhibit inhibitors initially injection insulin Iressa isolated kinase laboratory later leukemia leukotriene Lilly Lipitor lithium liver Macleod Marsilid medicine Merck metabolism mevastatin million molecule Morton nitroglycerin nitrous oxide Nobel Prize Novartis oral pancreas Parke-Davis patients penicillin Pfizer pharmaceutical Physiology production Prontosil prostaglandin protease protein Prozac receptor rheumatoid arthritis Roche scientists serotonin side effects Squibb statins streptomycin sulfanilamide Syntex synthesis tamoxifen Taxol tested therapy tion toxic trade name treating treatment tuberculosis tumors University Viagra virus Waksman