Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We UseOxford University Press, 7 сент. 2006 г. - Всего страниц: 336 The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. |
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Стр. 9
... compounds in the treatments of certain cancers. His observations specifically suggested the significance of compounds of this type for possible treatment of neoplastic disorders of the tissue that forms blood cells. In 1942, a year ...
... compounds in the treatments of certain cancers. His observations specifically suggested the significance of compounds of this type for possible treatment of neoplastic disorders of the tissue that forms blood cells. In 1942, a year ...
Стр. 10
... compounds were screened, and 45 anticancer drugs were discovered, a great boon to cancer treatment. Since then, scientists have prepared and experimented with thousands of mustard gas derivatives. To date, more than 100 nitrogen ...
... compounds were screened, and 45 anticancer drugs were discovered, a great boon to cancer treatment. Since then, scientists have prepared and experimented with thousands of mustard gas derivatives. To date, more than 100 nitrogen ...
Стр. 11
... . Paracelsus's antisyphilis drug contained mercury; Ehrlich's 606 was an arsenic compound. The gold complex, RS-Au-PEt3, is an antiarthritis drug; bis-(maltolato)oxovanadium (IV) is an insulin mimetic; and cancer drugs 11.
... . Paracelsus's antisyphilis drug contained mercury; Ehrlich's 606 was an arsenic compound. The gold complex, RS-Au-PEt3, is an antiarthritis drug; bis-(maltolato)oxovanadium (IV) is an insulin mimetic; and cancer drugs 11.
Стр. 12
... compound would be active against cancer at the time. Indeed, the discovery of the remarkable biological activities of the anticancer platinum drug Cisplatin makes an impressive chapter in the history of drug discovery. Vinca Alkaloids ...
... compound would be active against cancer at the time. Indeed, the discovery of the remarkable biological activities of the anticancer platinum drug Cisplatin makes an impressive chapter in the history of drug discovery. Vinca Alkaloids ...
Стр. 35
... compounds for other big pharmaceutical companies. In 1995, OSI entered an alliance with Pfizer to look for cancer drugs that work by blocking the EGFR signaling pathway. Medicinal chemists at Pfizer's Groton laboratory worked with OSI ...
... compounds for other big pharmaceutical companies. In 1995, OSI entered an alliance with Pfizer to look for cancer drugs that work by blocking the EGFR signaling pathway. Medicinal chemists at Pfizer's Groton laboratory worked with OSI ...
Содержание
3 | |
2 Drugs to Kill Germs | 43 |
From Nitroglycerin to Lipitor | 75 |
4 Sex and Drugs | 103 |
5 Drugs of the Mind | 129 |
6 Diabetes Drugs | 165 |
7 Anesthetics | 187 |
8 AntiInflammatory Drugs | 213 |
9 Reflections | 241 |
Chemical Structures | 245 |
Trademarks of the Drugs | 277 |
Bibliography | 281 |
Index | 295 |
Другие издания - Просмотреть все
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Часто встречающиеся слова и выражения
ACE inhibitors acid active agents alcohol anesthesia anesthetic antibacterial antibiotics antidepressants aphrodisiac approved aspirin Avastin Banting barbiturates became beta-blockers biological blood breast cancer Bristol-Myers Squibb calcium cancer drugs cause cells Chain chemical chemist chemistry chemotherapy chloroform chlorpromazine cholesterol clinical trials cocaine compounds cortisone depression developed diabetes discovered disease doses drug discovery EGFR enzyme estrogen ether extract Florey Gleevec guinea pigs haloperidol heart hormone human inhibit inhibitors initially injection insulin Iressa isolated kinase laboratory later leukemia leukotriene Lilly Lipitor lithium liver Macleod Marsilid medicine Merck metabolism mevastatin million molecule Morton nitroglycerin nitrous oxide Nobel Prize Novartis oral pancreas Parke-Davis patients penicillin Pfizer pharmaceutical Physiology production Prontosil prostaglandin protease protein Prozac receptor rheumatoid arthritis Roche scientists serotonin side effects Squibb statins streptomycin sulfanilamide Syntex synthesis tamoxifen Taxol tested therapy tion toxic trade name treating treatment tuberculosis tumors University Viagra virus Waksman