Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We UseOxford University Press, 7 сент. 2006 г. - Всего страниц: 336 The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. |
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Стр. 18
... enzymes involved in the synthesis of new DNA, and, as a result, many are derivatives of the building blocks of DNA itself, such as nucleotide-based inhibitors, or analogs of critical cofactors. In 1944, Richard Lewesohn, a surgeon at ...
... enzymes involved in the synthesis of new DNA, and, as a result, many are derivatives of the building blocks of DNA itself, such as nucleotide-based inhibitors, or analogs of critical cofactors. In 1944, Richard Lewesohn, a surgeon at ...
Стр. 24
... enzyme irreversibly and are called inactivators. In some cases they are dubbed as mechanism-based or “suicide” inhibitors when some of them are metabolized by the enzyme to reactive intermediates that bind covalently to the active site ...
... enzyme irreversibly and are called inactivators. In some cases they are dubbed as mechanism-based or “suicide” inhibitors when some of them are metabolized by the enzyme to reactive intermediates that bind covalently to the active site ...
Стр. 25
... enzyme—so there are fewer selectivity-related toxicities with the drugs. Protein Kinase Inhibitors, Monoclonal ... enzymes inside the cell that are capable of donating phosphate groups to target proteins. For instance, tyrosine kinases ...
... enzyme—so there are fewer selectivity-related toxicities with the drugs. Protein Kinase Inhibitors, Monoclonal ... enzymes inside the cell that are capable of donating phosphate groups to target proteins. For instance, tyrosine kinases ...
Стр. 26
... enzyme crucial to cell metabolism in which a defect would transform a healthy cell into a cancerous one. The theory was straightforward, and it made perfect sense. It explained how a single viral protein could make a normal cell ...
... enzyme crucial to cell metabolism in which a defect would transform a healthy cell into a cancerous one. The theory was straightforward, and it made perfect sense. It explained how a single viral protein could make a normal cell ...
Стр. 28
... enzyme with either an antibody or a small-molecule drug, one could stop the growth of cancer. An added bonus of the HER-2/neu enzyme is that the protein protrudes from the cell surface, making it an easy target for drugs to latch onto ...
... enzyme with either an antibody or a small-molecule drug, one could stop the growth of cancer. An added bonus of the HER-2/neu enzyme is that the protein protrudes from the cell surface, making it an easy target for drugs to latch onto ...
Содержание
3 | |
2 Drugs to Kill Germs | 43 |
From Nitroglycerin to Lipitor | 75 |
4 Sex and Drugs | 103 |
5 Drugs of the Mind | 129 |
6 Diabetes Drugs | 165 |
7 Anesthetics | 187 |
8 AntiInflammatory Drugs | 213 |
9 Reflections | 241 |
Chemical Structures | 245 |
Trademarks of the Drugs | 277 |
Bibliography | 281 |
Index | 295 |
Другие издания - Просмотреть все
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
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ACE inhibitors acid active agents alcohol anesthesia anesthetic antibacterial antibiotics antidepressants aphrodisiac approved aspirin Avastin Banting barbiturates became beta-blockers biological blood breast cancer Bristol-Myers Squibb calcium cancer drugs cause cells Chain chemical chemist chemistry chemotherapy chloroform chlorpromazine cholesterol clinical trials cocaine compounds cortisone depression developed diabetes discovered disease doses drug discovery EGFR enzyme estrogen ether extract Florey Gleevec guinea pigs haloperidol heart hormone human inhibit inhibitors initially injection insulin Iressa isolated kinase laboratory later leukemia leukotriene Lilly Lipitor lithium liver Macleod Marsilid medicine Merck metabolism mevastatin million molecule Morton nitroglycerin nitrous oxide Nobel Prize Novartis oral pancreas Parke-Davis patients penicillin Pfizer pharmaceutical Physiology production Prontosil prostaglandin protease protein Prozac receptor rheumatoid arthritis Roche scientists serotonin side effects Squibb statins streptomycin sulfanilamide Syntex synthesis tamoxifen Taxol tested therapy tion toxic trade name treating treatment tuberculosis tumors University Viagra virus Waksman