Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We UseOxford University Press, 7 сент. 2006 г. - Всего страниц: 336 The stories behind drug discovery are fascinating, full of human and scientific interest. This is a book on the history of drug discovery that highlights the intellectual splendor of discoverers as well as the human frailty associated them. History is replete with examples of breakthrough medicines that have saved millions of lives. Ether as an anesthetic by Morton; penicillin as an antibiotic by Fleming; and insulin as an anti-diabetic by Banting are just a few examples. The discoverers of these medicines are doubtlessly benefactors to mankind--for instance, without penicillin, 75% of us probably would not be alive because some of our parents or grandparents would have succumbed to infections. Dr. Jack Li, a medicinal chemist who is intimately involved with drug discovery, has assembled an astounding amount of facts and information behind important drugs through extensive literature research and interviews with many inventors of the drugs including Viagra and Lipitor. There have been many myths and inaccuracies associated with those legendary drugs. The inventors perspectives afforded this book an invaluable accuracy and insight because history is not history unless it is true. The text is supplemented by many anecdotes, pictures and postage stamps. Both specialist and layman will find Laughing Gas, Viagra, and Lipitor informative and entertaining. Students in chemistry, pharmacy, and medicine, workers in healthcare and high school science teachers will find this book most useful. |
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Стр. 12
... inhibit mitosis, the division of a cell's nucleus. Despite the insight that colchicine afforded into its mechanism of action, the drug itself has a narrow range of effectiveness against cancer. As a consequence, colchicine is mostly ...
... inhibit mitosis, the division of a cell's nucleus. Despite the insight that colchicine afforded into its mechanism of action, the drug itself has a narrow range of effectiveness against cancer. As a consequence, colchicine is mostly ...
Стр. 16
... inhibition of mitosis and induction of apoptosis. Taxol stops malignant tumors from growing by interfering with the microtubules that are responsible for dividing the chromosomes during cell division. This novel mechanism renewed ...
... inhibition of mitosis and induction of apoptosis. Taxol stops malignant tumors from growing by interfering with the microtubules that are responsible for dividing the chromosomes during cell division. This novel mechanism renewed ...
Стр. 19
... inhibit the growth of Lactobacillus casei. In 1948, they discovered that 2,4diaminopyrimidine, a folic acid antagonist, inhibited the growth of Lactobacillus casei. In 1952, Elion synthesized 6-mercaptopurine (Purinethol), which was an ...
... inhibit the growth of Lactobacillus casei. In 1948, they discovered that 2,4diaminopyrimidine, a folic acid antagonist, inhibited the growth of Lactobacillus casei. In 1952, Elion synthesized 6-mercaptopurine (Purinethol), which was an ...
Стр. 25
... inhibited protein kinase C (PKC). In 1988, Alexander Levitzki and colleagues from Israel showed that selectivity could be achieved for epidermal growth factor receptor (EGFR). In a Science paper,23 Levitzki and colleagues revealed that ...
... inhibited protein kinase C (PKC). In 1988, Alexander Levitzki and colleagues from Israel showed that selectivity could be achieved for epidermal growth factor receptor (EGFR). In a Science paper,23 Levitzki and colleagues revealed that ...
Стр. 28
... inhibiting the HER-2+ cell line. The researchers named the most potent clone muMAb 4D5, indicating that it was a murine monoclonal antibody. Chimera is a Greek word meaning something made from different parts. A chimeric antibody (chMAb) ...
... inhibiting the HER-2+ cell line. The researchers named the most potent clone muMAb 4D5, indicating that it was a murine monoclonal antibody. Chimera is a Greek word meaning something made from different parts. A chimeric antibody (chMAb) ...
Содержание
3 | |
2 Drugs to Kill Germs | 43 |
From Nitroglycerin to Lipitor | 75 |
4 Sex and Drugs | 103 |
5 Drugs of the Mind | 129 |
6 Diabetes Drugs | 165 |
7 Anesthetics | 187 |
8 AntiInflammatory Drugs | 213 |
9 Reflections | 241 |
Chemical Structures | 245 |
Trademarks of the Drugs | 277 |
Bibliography | 281 |
Index | 295 |
Другие издания - Просмотреть все
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Laughing Gas, Viagra, and Lipitor: The Human Stories Behind the Drugs We Use Jie Jack Li Ограниченный просмотр - 2006 |
Часто встречающиеся слова и выражения
ACE inhibitors acid active agents alcohol anesthesia anesthetic antibacterial antibiotics antidepressants aphrodisiac approved aspirin Avastin Banting barbiturates became beta-blockers biological blood breast cancer Bristol-Myers Squibb calcium cancer drugs cause cells Chain chemical chemist chemistry chemotherapy chloroform chlorpromazine cholesterol clinical trials cocaine compounds cortisone depression developed diabetes discovered disease doses drug discovery EGFR enzyme estrogen ether extract Florey Gleevec guinea pigs haloperidol heart hormone human inhibit inhibitors initially injection insulin Iressa isolated kinase laboratory later leukemia leukotriene Lilly Lipitor lithium liver Macleod Marsilid medicine Merck metabolism mevastatin million molecule Morton nitroglycerin nitrous oxide Nobel Prize Novartis oral pancreas Parke-Davis patients penicillin Pfizer pharmaceutical Physiology production Prontosil prostaglandin protease protein Prozac receptor rheumatoid arthritis Roche scientists serotonin side effects Squibb statins streptomycin sulfanilamide Syntex synthesis tamoxifen Taxol tested therapy tion toxic trade name treating treatment tuberculosis tumors University Viagra virus Waksman