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11C-PD153035 uptake and tumor EGFR expression levels related research
Of 11C-4-(3 - bromophenyl) -6,7 - bis methoxy-quinazoline (<a href="http://www.medchemexpress.com/product/PD153035.html">PD153035</a>) intake and epidermal growth factor receptor (EGFR) expression of the relationship between the method of in vitro determination of human breast cancer cells MDA-MB-468, MDA-MB-231 and A549 human lung adenocarcinoma cells with EGFR expression levels as well as the uptake of 11C-PD153035. were established tumor model in nude mice by tail vein injection of 11C-PD153035 PET line immediately after imaging, using regions of interest (ROI) method immediately after the injection and 10,20,30,40,50 and 60 min measured lesion / contralateral forelimb normal tissue radioactivity count (T / NT) ratio. imaging immediately after the animals were sacrificed to remove the tumor, the tumor uptake of radioactivity measured results of tumor cells in vitro uptake of 11C-PD153035 EGFR expression in tumor cells was significantly associated (r2 = 0.78, P = 0.001). in animals, T / NT and EGFR expression in tumor cells was significantly associated (r2 = 0.65, P = 0.004). vitro tumor tissue uptake of 11C-PD153035 EGFR expression in tumor cells was significantly associated (r2 = 0.64, P = 0.005). conclusions 11C-PD153035 uptake and tumor cells with EGFR expression levels were significantly associated, EGFR of 11C-PD153035 PET imaging is possible for cancer diagnosis and therapy.
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